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Fever mechanism of defense

Against an attack of viral or bacterial origin the immune system is activated and secretion of cytokines leads to the activation of cyclo-oxygenases (COX). These act on the temperature regulating mechanism of the hypothalamus centre and cause fever.

1 Administered by oral route, paracetamol leads to a preferential central inhibition of the COX enzyme. 2 This feature explains the anti-pyretic properties and powerful analgesic effects of paracetamol. In addition, it ensures the absence of gastro-intestinal toxicity and effects on blood coagulation 3.

Efficiency

Paracetamol, the active component of Pracetam®, is one of the safest and most reliable remedies used worldwide for the past 40 years in human medicine. CEVA offers you Pracetam®, a paracetamol solution developed for animal health. Pracetam® is an effective solution for treatment of fever during flu syndromes or acute respiratory disorders, together with other applications that we’ll explore further on.

Absorption

Parameters

Administration of drinkable 
Pracetam® 20% Oral Solution*

T 1/2 absorption

1 hr 30 min

T 1/2 absorption

4 hrs 30 min

C max

6.99 μg/ml

T max

4 hrs

F (bioavailability)

89%

A pharmacokinetic study carried out with Pracetam® 20% Oral Solution has shown a very rapid absorption of paracetamol during its administration to pigs by the oral route in their drinking water. The possibility of obtaining nearly maximum concentration peak (Cmax) is an additional factor for increased efficacy.

Hepatic and renal tolerance

Pracetam® has a strong antipyretic activity and almost none of the undesirable effects of the NSAIDs. A tolerance study observed symptoms of intolerance such as vomiting, diarrhoea, weight gain, rectal temperature and blood indicators. Pracetam® showed excellent results for hepatic tolerance.

Gastric tolerance

At the tested doses, Pracetam® does
not modify the speed of evacuation 
of a semi-solid meal in pigs.

A study conducted at Saint Gilles INRA station showed that Pracetam® has no effect on gastric emptying. The test results were convincing, as the evacuation of test meals occurred without a latency phase and no significant difference was noted concerning the half-emptying time.

Comparative / Summary table

COMPARATIVE TABLE

PRACETAM®

ACETYLSALICYLIC ACID

SODIUM SALICYLATE

KETOPROFEN

MELOXICAM ORAL 
SUSPENSION

CONTENT

10%, 20%, 40%

Variable
10% to 65%

Variable
80% to 100%

Variable
10% to 30%

15%

WITHDRAWAL PERIOD (PIGS)

0 day

Variable
0 day to 7 days

0 day

Variable
0 day to 1 day

5 days

DOSE

Unique

Very variable:
High dose and
very low dose

Unique

Unique.
Short treatment:
1 day of treatment with
possibility to renew if no
adverse effect.

Short treatment:
1 day of treatment with
possibility to renew if
necessary.

TOXICITY / RISKS (ULCERS)

No risk of ulcers.

Ulcerogenic.
Do not use in case of risk
of ulcers.

Ulcerogenic.
Stop the treatment in case
of dysfunction of stomach
or intestines.

Very ulcerogenic.
Do not use in case of risk
of ulcers.

Do not use in case of risk
of ulcers.

BLOOD COAGULATION

No anti-coagulation effect.

Do not use in case of hemorrhagic risk.

Do not use in case of hemorrhagic risk.
Reversible after 7 days.

Do not use in case of hemorrhagic risk.

Do not use in case of hemorrhagic risk.

REPRODUCTIVE TOXICITY

Safe for pregnant and lactating sows at 3 times the dose.

The use is not recommended during pregnancy and lactation.
Hemorrhagic risk for sows during delivery.

The use is not recommended during pregnancy and lactation.

The use is not recommended during pregnancy.
Hemorrhagic risk for sows during delivery.

Can be used during pregnancy and lactation.

SOLUBILITY

Soluble (dosing pump set at 3% or 5% for the oral solution and 5% for the powder)

Not soluble

Soluble

Soluble

Suspension for individual treatment (not soluble).
Administration in the feed or in the mouth (syringe).

ASSOCIATION

Possible with antibiotics or NSAIDs if necessary.

Concurrent use with other NSAIDs or nephrotoxic drugs is not recommended.
Do not associate with drugs which affect blood clotting.

Concurrent use with other NSAIDs or nephrotoxic drugs is not recommended.
Do not associate with drugs which affect blood clotting.

Concurrent use with other NSAIDs or nephrotoxic drugs is not recommended.
Do not associate with drugs which affect blood clotting.

Concurrent use with other NSAIDs or nephrotoxic drugs is not recommended.
Do not associate with drugs which affect blood clotting.

USES

pain

Inflamation

fever

pain

Inflamation

fever

pain

Inflamation

fever

pain

Inflamation

fever

pain

Inflamation

fever

Indications

  • Influenza-like syndrome
  • Respiratory disease
  • Non-specific fever
  • Pracetam® can be used from weaning to slaughter
  • Peripartum management
  • Post vaccinal reactions
  • Influenza-like syndrome
  • Respiratory disease
  • Pracetam® has been demonstrated safe in pregnant and lactating sows

Pracetam® Dose Calculator

Product Range

Pracetam® 20% Oral Solution

  • Pracetam® 20% Oral Solution for use in drinking water for pigs.
  • Available packaging: 1L and 5L bottles.
  • Highly soluble at ambient temperature in every kind of water qualities.
  • Stability in solution guaranteed for 24 hours for optimal efficiency.
  • The use of paracetamol in high concentrations with cold water can lead to the formation of crystals. Ceva recommends using Pracetam® Solution in dosing pumps set to 5% (3% minimum). The maximum solubility of Pracetam® Solution in cold water is 0.5 liters per 10 liters of water.

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